Detalhe da pesquisa
1.
The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin.
Proc Natl Acad Sci U S A
; 120(5): e2211939120, 2023 01 31.
Artigo
Inglês
| MEDLINE | ID: mdl-36693107
2.
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold.
Proc Natl Acad Sci U S A
; 120(37): e2305494120, 2023 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37669364
3.
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc Natl Acad Sci U S A
; 120(41): e2300258120, 2023 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37801475
4.
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J Biol Chem
; 300(2): 105531, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38072051
5.
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc Natl Acad Sci U S A
; 119(15): e2119952119, 2022 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35377792
6.
A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins.
Appl Magn Reson
; 55(1-3): 251-277, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38357006
7.
Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like ß-sheets.
J Biol Chem
; 298(10): 102396, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35988647
8.
Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways.
J Biol Chem
; 298(7): 102111, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35690147
9.
Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA.
J Biol Chem
; 298(2): 101464, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34864059
10.
Prospecting for natural products by genome mining and microcrystal electron diffraction.
Nat Chem Biol
; 17(8): 872-877, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34312563
11.
Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Mol Cell
; 57(6): 1011-1021, 2015 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25728769
12.
The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing.
Proteins
; 90(7): 1457-1467, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35194841
13.
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.
Nature
; 539(7627): 43-47, 2016 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27680699
14.
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J Biol Chem
; 295(31): 10662-10676, 2020 07 31.
Artigo
Inglês
| MEDLINE | ID: mdl-32493775
15.
Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.
PLoS Pathog
; 15(4): e1007723, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31002736
16.
Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE.
Nat Chem Biol
; 15(2): 132-140, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30559425
17.
Structure of the toxic core of α-synuclein from invisible crystals.
Nature
; 525(7570): 486-90, 2015 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-26352473
18.
Cooperative DNA binding by proteins through DNA shape complementarity.
Nucleic Acids Res
; 47(16): 8874-8887, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31616952
19.
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J Biol Chem
; 294(44): 16451-16464, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31537646
20.
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat Methods
; 14(4): 399-402, 2017 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28192420